Fibrinogen beta chain

Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.

FGB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FZA, 1FZB, 1FZC, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3BVH, 3E1I, 3GHG, 3H32, 3HUS
Identifiers
Aliases	FGB, HEL-S-78p, fibrinogen beta chain
External IDs	OMIM: 134830; MGI: 99501; HomoloGene: 3772; GeneCards: FGB; OMA:FGB - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 154,562,956 bp[1] End 154,571,086 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E3|3 36.98 cM Start 82,947,448 bp[2] End 82,957,170 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver beta cell gonad human kidney kidney tubule testicle metanephric glomerulus epithelium of colon decidua body of stomach Top expressed in left lobe of liver human fetus yolk sac fetal liver hematopoietic progenitor cell gallbladder abdominal wall sexually immature organism primitive streak embryo semi-lunar valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity chaperone binding structural molecule activity protein binding signaling receptor binding cell adhesion molecule binding extracellular matrix structural constituent Cellular component cytoplasm platelet alpha granule extracellular vesicle blood microparticle plasma membrane fibrinogen complex extracellular region cell surface cell cortex extracellular exosome platelet alpha granule lumen external side of plasma membrane extracellular space endoplasmic reticulum synapse collagen-containing extracellular matrix Biological process hemostasis negative regulation of endothelial cell apoptotic process positive regulation of peptide hormone secretion protein polymerization positive regulation of heterotypic cell-cell adhesion adaptive immune response fibrinolysis immune system process platelet degranulation blood coagulation extracellular matrix organization cellular response to leptin stimulus response to calcium ion positive regulation of substrate adhesion-dependent cell spreading negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of vasoconstriction cellular response to interleukin-1 positive regulation of protein secretion positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis blood coagulation, fibrin clot formation plasminogen activation innate immune response cell-matrix adhesion platelet aggregation signal transduction induction of bacterial agglutination platelet activation toll-like receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2244 110135 Ensembl ENSG00000171564 ENSMUSG00000033831 UniProt P02675 Q8K0E8 RefSeq (mRNA) NM_001184741 NM_005141 NM_181849 RefSeq (protein) NP_001171670 NP_005132 NP_001369688 NP_001369689 NP_001369690 NP_001369691 NP_001369692 NP_001369693 NP_001369694 NP_862897 Location (UCSC) Chr 4: 154.56 – 154.57 Mb Chr 3: 82.95 – 82.96 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.^[5]

Interactions

Fibrinogen beta chain has been shown to interact with Lipoprotein(a).^[6]

See also

• Fibrin
• Fibrinogen alpha chain
• Fibrinogen gamma chain