Formiminoglutamic acid

Formiminoglutamic acid (FIGLU; conjugate base, formiminoglutamate) is an intermediate in the catabolism of L-histidine to L-glutamic acid. It thus is also a biomarker for intracellular levels of folate. The FIGLU test is used to identify vitamin B₁₂ deficiency, folate deficiency, and liver failure or liver disease.^[1][2] It is elevated with folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate and a decrease in homocysteine.^[3]

Formiminoglutamic acid

Names
IUPAC name N-(aminomethylidene)-L-glutamic acid
Other names FIGLU
Identifiers
CAS Number	816-90-0 Y
3D model (JSmol)	Interactive image
ChemSpider	388370 N
ECHA InfoCard	100.011.308
MeSH	Formiminoglutamic+acid
PubChem CID	909
UNII	YV703N7VOG Y
SMILES C(CC(=O)O)C(C(=O)O)N=CN
Properties
Chemical formula	C6H10N2O4
Molar mass	174.156 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

See also

• Formiminotransferase cyclodeaminase
• Glutamate-1-semialdehyde
• Glutamic acid
• Imidazol-4-one-5-propionic acid