G3BP1

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.^[5][6][7]

G3BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q90, 4FCJ, 4FCM, 4IIA
Identifiers
Aliases	G3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1
External IDs	OMIM: 608431; MGI: 1351465; HomoloGene: 38096; GeneCards: G3BP1; OMA:G3BP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 151,771,045 bp[1] End 151,812,911 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 55,360,511 bp[2] End 55,395,664 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone epithelium of colon ganglionic eminence gonad islet of Langerhans stromal cell of endometrium Achilles tendon tonsil muscle of thigh gastrocnemius muscle Top expressed in Ileal epithelium ventricular zone corneal stroma lactiferous gland embryo embryo tail of embryo plantaris muscle epiblast extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity DNA helicase activity protein binding nucleic acid binding nuclease activity endonuclease activity ATP binding hydrolase activity mRNA binding RNA binding Cellular component membrane focal adhesion plasma membrane intracellular anatomical structure cytoplasmic stress granule nucleus cytoplasm cytosol perikaryon ribonucleoprotein complex Biological process nucleic acid phosphodiester bond hydrolysis Ras protein signal transduction negative regulation of canonical Wnt signaling pathway DNA duplex unwinding transport stress granule assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10146 27041 Ensembl ENSG00000145907 ENSMUSG00000018583 UniProt Q13283 P97855 RefSeq (mRNA) NM_005754 NM_198395 NM_013716 RefSeq (protein) NP_005745 NP_938405 NP_038744 Location (UCSC) Chr 5: 151.77 – 151.81 Mb Chr 11: 55.36 – 55.4 Mb PubMed search [3] [4]
Wikidata
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This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.^[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[7]

G3BP1 can initiate stress granule formation and labeled G3BP1 is commonly used as a marker for stress granules.^[9]

Interactions

G3BP1 has been shown to interact with USP10.^[10] It also interacts with SND1[5].