USP10

Ubiquitin specific peptidase 10, also known as USP10, is an enzyme which in humans is encoded by the USP10 gene.^[5]

USP10
Identifiers
Aliases	USP10, UBPO, ubiquitin specific peptidase 10
External IDs	OMIM: 609818; MGI: 894652; HomoloGene: 31294; GeneCards: USP10; OMA:USP10 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 84,699,986 bp[1] End 84,779,922 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 120,637,099 bp[2] End 120,684,299 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence secondary oocyte blood epithelium of colon gastrocnemius muscle monocyte sperm muscle of thigh stromal cell of endometrium Top expressed in tail of embryo epiblast genital tubercle neural layer of retina primitive streak yolk sac abdominal wall lens ventricular zone morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity transmembrane transporter binding p53 binding peptidase activity protein binding cysteine-type endopeptidase activity hydrolase activity RNA binding thiol-dependent deubiquitinase Cellular component cytoplasm endosome nucleoplasm early endosome nucleus cytosol protein-containing complex Biological process ubiquitin-dependent protein catabolic process proteolysis autophagy regulation of autophagy translesion synthesis cellular response to interleukin-1 cellular response to DNA damage stimulus negative regulation of I-kappaB kinase/NF-kappaB signaling DNA repair protein deubiquitination DNA damage response, signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9100 22224 Ensembl ENSG00000103194 ENSMUSG00000031826 UniProt Q14694 P52479 RefSeq (mRNA) NM_001272075 NM_005153 NM_009462 NM_001310630 RefSeq (protein) NP_001259004 NP_005144 NP_001297559 NP_033488 Location (UCSC) Chr 16: 84.7 – 84.78 Mb Chr 8: 120.64 – 120.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.^[5]

Interactions

USP10 has been shown to interact with G3BP1.^[6] In the endothelium, USP10 regulates Notch signaling by slowing down the degradation of the intracellular domain of NOTCH1. ^[7]