GABBR1

Gamma-aminobutyric acid B receptor, 1 (GABA_B1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

GABBR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MQE, 4MQF, 4MR7, 4MR9, 4MRM, 4MS1, 4MS3, 4MS4, 4PAS
Identifiers
Aliases	GABBR1, GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2, gamma-aminobutyric acid type B receptor subunit 1
External IDs	OMIM: 603540; MGI: 1860139; HomoloGene: 1132; GeneCards: GABBR1; OMA:GABBR1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 29,555,629 bp[1] End 29,633,976 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 19.16 cM Start 37,356,858 bp[2] End 37,385,959 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe cingulate gyrus anterior cingulate cortex Brodmann area 9 body of uterus right ovary canal of the cervix left uterine tube left ovary Top expressed in habenula superior frontal gyrus dentate gyrus of hippocampal formation granule cell nucleus of stria terminalis entorhinal cortex primary visual cortex cerebellar cortex medial dorsal nucleus central gray substance of midbrain CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein binding G protein-coupled GABA receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Cellular component cytoplasm integral component of membrane G protein-coupled receptor dimeric complex postsynaptic membrane cell projection membrane plasma membrane synapse integral component of plasma membrane extracellular region cell junction dendrite G protein-coupled receptor heterodimeric complex presynaptic membrane presynapse Schaffer collateral - CA1 synapse GABA-ergic synapse Biological process gamma-aminobutyric acid signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway signal transduction negative regulation of adenylate cyclase activity G protein-coupled receptor signaling pathway regulation of postsynaptic membrane potential neuron-glial cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2550 54393 Ensembl ENSG00000237112 ENSG00000206511 ENSG00000206466 ENSG00000232632 ENSG00000232569 ENSG00000237051 ENSG00000204681 ENSMUSG00000024462 UniProt Q9UBS5 Q9WV18 RefSeq (mRNA) NM_001470 NM_021903 NM_021904 NM_021905 NM_001319053 NM_019439 RefSeq (protein) NP_001305982 NP_001461 NP_068703 NP_068704 NP_062312 Location (UCSC) Chr 6: 29.56 – 29.63 Mb Chr 17: 37.36 – 37.39 Mb PubMed search [3] [4]
Wikidata
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Function

GABA_B1 is a receptor for Gamma-aminobutyric acid. Upon binding, GABA_B1 will produce a slow and prolonged inhibitory effect. GABA_B1 is one part of a heterodimer, which is the GABA_B receptor, consisting of it and the related GABA_B2 protein. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.^[5]

Interactions

GABBR1 has been shown to interact with ATF4^[6] and GABBR2.^[7]

See also

• GABAB receptor