GABBR2

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABA_B2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.^[5]

GABBR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F11, 4F12, 4MQE, 4MQF, 4MR7, 4MR8, 4MR9, 4MRM, 4MS1, 4MS3, 4MS4, 4PAS
Identifiers
Aliases	GABBR2, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, gamma-aminobutyric acid type B receptor subunit 2, EIEE59, NDPLHS, DEE59
External IDs	OMIM: 607340; MGI: 2386030; HomoloGene: 55902; GeneCards: GABBR2; OMA:GABBR2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.33 Start 98,288,109 bp[1] End 98,708,935 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 46,662,305 bp[2] End 46,991,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 lateral nuclear group of thalamus middle temporal gyrus endothelial cell superior frontal gyrus Brodmann area 46 Brodmann area 10 orbitofrontal cortex parietal lobe postcentral gyrus Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex cerebellum hippocampus proper superior frontal gyrus cerebellar cortex hypothalamus striatum of neuraxis olfactory bulb neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding G protein-coupled receptor activity G protein-coupled GABA receptor activity signal transducer activity protein heterodimerization activity Cellular component cytoplasm integral component of membrane neuron projection cell junction G protein-coupled receptor heterodimeric complex plasma membrane postsynaptic membrane synapse integral component of plasma membrane membrane GABA receptor complex Biological process gamma-aminobutyric acid signaling pathway G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity signal transduction chemical synaptic transmission neuron-glial cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9568 242425 Ensembl ENSG00000136928 ENSMUSG00000039809 UniProt O75899 Q80T41 RefSeq (mRNA) NM_005458 NM_001081141 RefSeq (protein) NP_005449 NP_001074610 Location (UCSC) Chr 9: 98.29 – 98.71 Mb Chr 4: 46.66 – 46.99 Mb PubMed search [3] [4]
Wikidata
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Function

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]^[5]

Interactions

GABBR2 has been shown to interact with GABBR1.^[6]

See also

• GABAB receptor