GADD45B

Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene.^[5][6][7]

GADD45B
Identifiers
Aliases	GADD45B, GADD45BETA, MYD118, growth arrest and DNA damage inducible beta
External IDs	OMIM: 604948; MGI: 107776; HomoloGene: 7433; GeneCards: GADD45B; OMA:GADD45B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,476,122 bp[1] End 2,478,259 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,765,907 bp[2] End 80,768,038 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava gastric mucosa saphenous vein tibial arteries left uterine tube ascending aorta pericardium pancreatic ductal cell right lobe of thyroid gland right auricle of heart Top expressed in superior surface of tongue gallbladder granulocyte internal carotid artery external carotid artery fossa condyle molar mesenteric lymph nodes decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus Biological process multicellular organism development positive regulation of apoptotic process positive regulation of p38MAPK cascade response to stress cell differentiation positive regulation of JNK cascade negative regulation of protein kinase activity apoptotic process regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4616 17873 Ensembl ENSG00000099860 ENSMUSG00000015312 UniProt O75293 P22339 RefSeq (mRNA) NM_015675 NM_008655 RefSeq (protein) NP_056490 NP_032681 Location (UCSC) Chr 19: 2.48 – 2.48 Mb Chr 10: 80.77 – 80.77 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.^[5]

Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. Hence GADD45B is implicated in affecting synaptic plasticity.^[8]

Interactions

GADD45B has been shown to interact with:

• ASK1,^[9]
• GADD45GIP1,^[10]
• MAP2K7^[9] and
• MAP3K4.^[7]

See also

• Gadd45