GADD45GIP1

Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.^[5][6][7]

GADD45GIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	GADD45GIP1, CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1, GADD45G interacting protein 1
External IDs	OMIM: 605162; MGI: 1914947; HomoloGene: 33474; GeneCards: GADD45GIP1; OMA:GADD45GIP1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,953,119 bp[1] End 12,957,223 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 85,558,151 bp[2] End 85,562,111 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh mucosa of transverse colon left ventricle gastrocnemius muscle right auricle of heart triceps brachii muscle anterior cingulate cortex olfactory zone of nasal mucosa right adrenal gland Top expressed in left lobe of liver primary oocyte digastric muscle extraocular muscle interventricular septum right ventricle temporal muscle myocardium of ventricle sternocleidomastoid muscle adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component mitochondrial matrix mitochondrial ribosome nucleus mitochondrion ribosome Biological process cell cycle mitochondrial translational elongation mitochondrial translational termination viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90480 102060 Ensembl ENSG00000179271 ENSMUSG00000033751 UniProt Q8TAE8 Q9CR59 RefSeq (mRNA) NM_052850 NM_183358 RefSeq (protein) NP_443082 NP_899202 Location (UCSC) Chr 19: 12.95 – 12.96 Mb Chr 8: 85.56 – 85.56 Mb PubMed search [3] [4]
Wikidata
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GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.^[8]

Interactions

GADD45GIP1 has been shown to interact with GADD45G,^[9] GADD45B^[9] and GADD45A.^[9]