GAF domain

The GAF domain is a type of protein domain that is found in a wide range of proteins from all species.^[2] The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain solved by Ho and colleagues showed that this domain shared a similar fold with the PAS domain.^[3] In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which binds both cGMP and cAMP.^[4][5]

GAF domain
3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains.[1]
Identifiers
Symbol	GAF
Pfam	PF01590
Pfam clan	CL0161
InterPro	IPR003018
SMART	GAF
SCOP2	1fl4 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Examples

Human proteins containing this domain include:

• PDE2A, PDE5A, PDE6A, PDE6B, PDE6C, PDE10A, PDE11A