GAL3ST1

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.^[5][6][7]

GAL3ST1
Identifiers
Aliases	GAL3ST1, CST, galactose-3-O-sulfotransferase 1
External IDs	OMIM: 602300; MGI: 1858277; HomoloGene: 3574; GeneCards: GAL3ST1; OMA:GAL3ST1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,554,635 bp[1] End 30,574,665 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,933,636 bp[2] End 3,949,326 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment tibial nerve gonad putamen duodenum nucleus accumbens amygdala caudate nucleus substantia nigra sural nerve Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach right kidney duodenum lumbar subsegment of spinal cord anterior horn of spinal cord deep cerebellar nuclei sciatic nerve optic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity galactosylceramide sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus integral component of plasma membrane membrane Biological process glycolipid biosynthetic process myelination galactosylceramide biosynthetic process protein N-linked glycosylation spermatogenesis sphingolipid metabolic process lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9514 53897 Ensembl ENSG00000128242 ENSMUSG00000049721 UniProt Q99999 Q9JHE4 RefSeq (mRNA) NM_004861 NM_001318103 NM_001318104 NM_001318105 NM_001318106 NM_001318107 NM_001318108 NM_001318109 NM_001318110 NM_001318111 NM_001318112 NM_001318113 NM_001318114 NM_001318115 NM_001318116 NM_001177691 NM_001177703 NM_016922 NM_001382290 NM_001382291 RefSeq (protein) NP_001305032 NP_001305033 NP_001305034 NP_001305035 NP_001305036 NP_001305037 NP_001305038 NP_001305039 NP_001305040 NP_001305041 NP_001305042 NP_001305043 NP_001305044 NP_001305045 NP_004852 NP_001171162 NP_001171174 NP_058618 NP_001369219 NP_001369220 Location (UCSC) Chr 22: 30.55 – 30.57 Mb Chr 11: 3.93 – 3.95 Mb PubMed search [3] [4]
Wikidata
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Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[7]