GATAD2B

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.^[5][6][7]

GATAD2B
Identifiers
Aliases	GATAD2B, MRD18, P66beta, p68, GATA zinc finger domain containing 2B, GANDS
External IDs	OMIM: 614998; MGI: 2443225; HomoloGene: 32484; GeneCards: GATAD2B; OMA:GATAD2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,789,030 bp[1] End 153,923,360 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 90,200,485 bp[2] End 90,270,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon corpus callosum bone marrow cells skeletal muscle tissue blood tonsil ganglionic eminence sural nerve ventricular zone Cerebellum Top expressed in secondary oocyte zygote ascending aorta aortic valve Rostral migratory stream primary oocyte supraoptic nucleus genital tubercle tail of embryo cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleosomal DNA binding sequence-specific DNA binding zinc ion binding protein binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear speck nucleus nucleoplasm NuRD complex protein-containing complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57459 229542 Ensembl ENSG00000143614 ENSG00000261992 ENSMUSG00000042390 UniProt Q8WXI9 Q8VHR5 RefSeq (mRNA) NM_020699 NM_139304 NM_001379655 NM_001379656 NM_001379657 RefSeq (protein) NP_065750 NP_647465 NP_001366584 NP_001366585 NP_001366586 Location (UCSC) Chr 1: 153.79 – 153.92 Mb Chr 3: 90.2 – 90.27 Mb PubMed search [3] [4]
Wikidata
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Interactions

GATAD2B has been shown to interact with Methyl-CpG-binding domain protein 2,^[6][8] MBD3,^[6][8] RBBP7^[6] and RBBP4.^[6]