RBBP7

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.^[5]

RBBP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CFS, 3CFV
Identifiers
Aliases	RBBP7, RbAp46, retinoblastoma binding protein 7, RB binding protein 7, chromatin remodeling factor
External IDs	OMIM: 300825; MGI: 1194910; HomoloGene: 55702; GeneCards: RBBP7; OMA:RBBP7 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 16,839,283 bp[1] End 16,870,362 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F4 Start 161,543,398 bp[2] End 161,562,088 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right adrenal gland right adrenal cortex left adrenal cortex corpus epididymis seminal vesicula endothelial cell right testis left ovary Top expressed in primitive streak migratory enteric neural crest cell medullary collecting duct condyle ureter Paneth cell internal carotid artery fossa external carotid artery vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding histone deacetylase activity Cellular component NuRD complex ESC/E(Z) complex nucleus nucleoplasm cytosol Biological process regulation of transcription, DNA-templated response to steroid hormone cellular heat acclimation negative regulation of transcription by RNA polymerase II CENP-A containing chromatin assembly transcription, DNA-templated multicellular organism development DNA replication negative regulation of gene expression, epigenetic negative regulation of cell growth cell population proliferation negative regulation of transcription, DNA-templated regulation of signal transduction by p53 class mediator histone deacetylation post-translational protein modification negative regulation of G0 to G1 transition chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5931 245688 Ensembl ENSG00000102054 ENSMUSG00000031353 UniProt Q16576 Q60973 RefSeq (mRNA) NM_001198719 NM_002893 NM_009031 RefSeq (protein) NP_001185648 NP_002884 NP_033057 Location (UCSC) Chr X: 16.84 – 16.87 Mb Chr X: 161.54 – 161.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.^[6]

Interactions

RBBP7 has been shown to interact with:

• BRCA1,^[7][8][9]
• GATAD2B,^[10]
• HDAC1,^{[11][12][13][14]}
• MTA2,^[11][13]
• Retinoblastoma protein,^[5][7]
• SAP30,^[13][15][16] and
• SIN3A.^[15][16]