GCN1L1

Translational activator GCN1 is a protein that in humans is encoded by the GCN1L1 gene.^[5][6]

GCN1
Identifiers
Aliases	GCN1, GCN1L, PRIC295, GCN1L1, eIF2 alpha kinase activator homolog, GCN1 activator of EIF2AK4
External IDs	OMIM: 605614; MGI: 2444248; HomoloGene: 5887; GeneCards: GCN1; OMA:GCN1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 120,127,202 bp[1] End 120,194,715 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 115,703,313 bp[2] End 115,760,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone tendon of biceps brachii sural nerve pylorus gastrocnemius muscle cardia stromal cell of endometrium right lobe of thyroid gland nipple granulocyte Top expressed in neural layer of retina Rostral migratory stream ventricular zone lumbar subsegment of spinal cord spermatid muscle of thigh yolk sac superior frontal gyrus secondary oocyte primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribosome binding translation factor activity, RNA binding protein kinase binding protein kinase regulator activity RNA binding cadherin binding Cellular component polysome ribosome membrane cytoplasm cytosol Biological process positive regulation of transcription from RNA polymerase II promoter in response to stress positive regulation of kinase activity cellular response to stress cellular response to amino acid starvation regulation of protein kinase activity cellular response to leucine starvation regulation of translation protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10985 231659 Ensembl ENSG00000089154 ENSMUSG00000041638 UniProt Q92616 E9PVA8 RefSeq (mRNA) NM_006836 NM_172719 RefSeq (protein) NP_006827 NP_766307 Location (UCSC) Chr 12: 120.13 – 120.19 Mb Chr 5: 115.7 – 115.76 Mb PubMed search [3] [4]
Wikidata
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Interactions

GCN1L1 has been shown to interact with CDC5L.^[7]