CDC5L

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.^[5][6][7]

CDC5L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIM, 2DIN
Identifiers
Aliases	CDC5L, CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1, cell division cycle 5 like
External IDs	OMIM: 602868; MGI: 1918952; HomoloGene: 13291; GeneCards: CDC5L; OMA:CDC5L - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 44,387,706 bp[1] End 44,450,425 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B3 Start 45,702,810 bp[2] End 45,744,663 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell sperm tibia tendon of biceps brachii internal globus pallidus secondary oocyte amniotic fluid glutes biceps brachii Brodmann area 23 Top expressed in genital tubercle tail of embryo maxillary prominence mandibular prominence primitive streak morula renal corpuscle morula vestibular membrane of cochlear duct blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein phosphatase 1 binding leucine zipper domain binding WD40-repeat domain binding protein binding transcription corepressor binding protein kinase binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm nuclear speck catalytic step 2 spliceosome membrane Prp19 complex nucleoplasm protein-DNA complex perinuclear region of cytoplasm DNA replication factor A complex spliceosomal complex nucleus U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome cellular response to nerve growth factor stimulus regulation of transcription, DNA-templated mRNA processing cellular response to fibroblast growth factor stimulus transcription, DNA-templated cellular response to interleukin-2 cellular response to prolactin cellular response to DNA damage stimulus cellular response to wortmannin mitotic cell cycle cell cycle DNA repair cell differentiation RNA splicing regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 988 71702 Ensembl ENSG00000096401 ENSMUSG00000023932 UniProt Q99459 Q6A068 RefSeq (mRNA) NM_001253 NM_152810 RefSeq (protein) NP_001244 NP_690023 Location (UCSC) Chr 6: 44.39 – 44.45 Mb Chr 17: 45.7 – 45.74 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G₂/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G₂/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.^[7]

Interactions

CDC5L has been shown to interact with:

• ASF/SF2,^[8]
• BZW1,^[8]
• CWC15,^[8]
• DNA-PKcs,^[8]
• DYNC1H1,^[8]
• GCN1L1,^[8]
• HSPA8,^[8]
• ILF2,^[8]
• PLRG1,^{[8][9][10][11]}
• PPM1D,^[8]
• PPP1CA,^[8]
• PRPF19,^[8]
• RBMX^[8] and
• RPL12,^[8]
• RPL13,^[8]
• RPS16,^[8]
• RPS25,^[8]
• SF3A1,^[8]
• SF3B1,^[8]
• SF3B2,^[8]
• SF3B4,^[8]
• SFPQ,^[8]
• SRSF2,^[8]
• SNRPA1,^[8]
• SNRPD3,^[8]
• SRRM1,^[8]
• Small nuclear ribonucleoprotein D1,^[8]
• Small nuclear ribonucleoprotein D2,^[8]
• Small nuclear ribonucleoprotein polypeptide A,^[8]
• TOP2A,^[8] and
• TTF2.^[12]

See also

• G2/M checkpoint