GDF10

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.^[5]

GDF10
Identifiers
Aliases	GDF10, BMP-3b, BMP3B, growth differentiation factor 10, BIP
External IDs	OMIM: 601361; MGI: 95684; HomoloGene: 3640; GeneCards: GDF10; OMA:GDF10 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.22 Start 47,300,197 bp[1] End 47,313,577 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 20.8 cM Start 33,645,544 bp[2] End 33,659,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right lung upper lobe of left lung tibial nerve tibia body of pancreas popliteal artery tibial arteries Descending thoracic aorta subcutaneous adipose tissue Top expressed in calvaria efferent ductule body wall ankle lower lip cerebellar vermis tunica adventitia of aorta lobe of cerebellum internal carotid artery ankle joint More reference expression data BioGPS n/a
Gene ontology Molecular function transforming growth factor beta receptor binding cytokine activity growth factor activity Cellular component extracellular region extracellular space extracellular matrix collagen-containing extracellular matrix Biological process regulation of apoptotic process skeletal system development positive regulation of pathway-restricted SMAD protein phosphorylation regulation of MAPK cascade transforming growth factor beta receptor signaling pathway SMAD protein signal transduction fat cell differentiation cell development BMP signaling pathway osteoblast differentiation negative regulation of osteoblast differentiation ossification regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2662 14560 Ensembl ENSG00000266524 ENSMUSG00000021943 UniProt P55107 P97737 RefSeq (mRNA) NM_004962 NM_145741 RefSeq (protein) NP_004953 NP_665684 Location (UCSC) Chr 10: 47.3 – 47.31 Mb Chr 14: 33.65 – 33.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis.^[5][6] GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.^[5]

In mice, GDF10 mRNA is abundant in the brain, inner ear, uterus, prostate, neural tissues, blood vessels and adipose tissue with low expression in spleen and liver. It is also present in bone of both adults and neonatal mice.^[5] Human GDF10 mRNA is found in the cochlea and lung of foetuses, and in testis, retina, pineal gland, and other neural tissues of adults.^[7]