GGA1

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.^[5][6][7]

GGA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J2J, 1JWF, 1JWG, 1NA8, 1NAF, 1NWM, 1O3X, 1OM9, 1OXZ, 1PY1, 1UJJ, 1UJK, 1X79, 2DWX, 2DWY, 3G2S, 3G2T, 3G2U, 3G2V, 3G2W
Identifiers
Aliases	GGA1, golgi associated, gamma adaptin ear containing, ARF binding protein 1
External IDs	OMIM: 606004; MGI: 2146207; HomoloGene: 39250; GeneCards: GGA1; OMA:GGA1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,608,725 bp[1] End 37,633,564 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,761,390 bp[2] End 78,778,785 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell left testis right testis endothelial cell right uterine tube mucosa of ileum right hemisphere of cerebellum pituitary gland gingival epithelium anterior pituitary Top expressed in granulocyte muscle of thigh lip pyloric antrum yolk sac superior frontal gyrus ventricular zone dentate gyrus of hippocampal formation granule cell primary visual cortex esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity molecular function Cellular component endosome Golgi apparatus endosome membrane intracellular anatomical structure membrane intracellular membrane-bounded organelle clathrin adaptor complex nucleoplasm early endosome membrane early endosome cytosol protein-containing complex Biological process protein transport intracellular protein transport toxin transport positive regulation of protein catabolic process vesicle-mediated transport transport Golgi to plasma membrane transport protein localization protein localization to cell surface retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport protein localization to ciliary membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26088 106039 Ensembl ENSG00000100083 ENSMUSG00000033128 UniProt Q9UJY5 Q8R0H9 RefSeq (mRNA) NM_001001560 NM_001001561 NM_001172687 NM_001172688 NM_013365 NM_001363771 NM_145929 RefSeq (protein) NP_001001560 NP_001166158 NP_001166159 NP_037497 NP_001350700 NP_666041 Location (UCSC) Chr 22: 37.61 – 37.63 Mb Chr 15: 78.76 – 78.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[8]

Interactions

GGA1 has been shown to interact with Sortilin 1,^[9] BACE2,^[10] RABEP1^[11] and ARF3.^[12][13]