ARF3

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.^[5][6]

ARF3
Identifiers
Aliases	ARF3, ADP ribosylation factor 3
External IDs	OMIM: 103190; MGI: 99432; HomoloGene: 68195; GeneCards: ARF3; OMA:ARF3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,935,723 bp[1] End 48,957,487 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 98,634,515 bp[2] End 98,661,095 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex entorhinal cortex postcentral gyrus Brodmann area 10 superior frontal gyrus Brodmann area 46 Region I of hippocampus proper frontal pole nucleus accumbens dorsolateral prefrontal cortex Top expressed in nucleus accumbens dorsal striatum dentate gyrus of hippocampal formation granule cell olfactory tubercle prefrontal cortex superior frontal gyrus lateral septal nucleus anterior amygdaloid area piriform cortex Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component cytoplasm perinuclear region of cytoplasm Golgi membrane Golgi apparatus extracellular exosome intracellular anatomical structure plasma membrane Biological process protein transport phosphatidylinositol biosynthetic process small GTPase mediated signal transduction vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum transport intracellular protein transport Golgi to plasma membrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 377 11842 Ensembl ENSG00000134287 ENSMUSG00000051853 UniProt P61204 P61205 RefSeq (mRNA) NM_001659 NM_007478 NM_001355510 RefSeq (protein) NP_001650 NP_031504 NP_001342439 Location (UCSC) Chr 12: 48.94 – 48.96 Mb Chr 15: 98.63 – 98.66 Mb PubMed search [3] [4]
Wikidata
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Function

ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns.^[6]

Interactions

ARF3 has been shown to interact with:

• ARFIP1,^[7][8]
• ARFIP2,^[7]
• GGA1,^[9][10]
• GGA3,^[9][10] and
• KIF23.^[11]