GGA2

ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.^[5][6][7]

GGA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MHQ
Identifiers
Aliases	GGA2, VEAR, golgi associated, gamma adaptin ear containing, ARF binding protein 2
External IDs	OMIM: 606005; MGI: 1921355; HomoloGene: 22860; GeneCards: GGA2; OMA:GGA2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.2 Start 23,463,542 bp[1] End 23,521,995 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 121,585,945 bp[2] End 121,620,445 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas tendon of biceps brachii right lobe of thyroid gland tonsil left lobe of thyroid gland lymph node left ovary right ovary right hemisphere of cerebellum right adrenal cortex Top expressed in otic placode yolk sac saccule otic vesicle primitive streak epithelium of stomach molar epiblast transitional epithelium of urinary bladder medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component endosome trans-Golgi network Golgi apparatus endosome membrane intracellular anatomical structure membrane clathrin-coated vesicle clathrin adaptor complex early endosome membrane Biological process protein transport intracellular protein transport vesicle-mediated transport protein localization to cell surface Golgi to plasma membrane protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23062 74105 Ensembl ENSG00000103365 ENSMUSG00000030872 UniProt Q9UJY4 Q6P5E6 RefSeq (mRNA) NM_015044 NM_138640 NM_028758 RefSeq (protein) NP_055859 NP_083034 Location (UCSC) Chr 16: 23.46 – 23.52 Mb Chr 7: 121.59 – 121.62 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.^[7]

Interactions

GGA2 has been shown to interact with RABEP1,^[8] Sortilin 1,^[9][10] BACE2^[11] and CLINT1.^[12][13]