CLINT1

Clathrin interactor 1 (CLINT1), also known as EPSIN4, is a protein which in humans is encoded by the CLINT1 gene.^[5][6][7]

CLINT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XGW, 2QY7, 2V8S
Identifiers
Aliases	CLINT1, CLINT, ENTH, EPN4, EPNR, clathrin interactor 1
External IDs	OMIM: 607265; MGI: 2144243; HomoloGene: 133740; GeneCards: CLINT1; OMA:CLINT1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 157,785,743 bp[1] End 157,859,145 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.1 Start 45,742,791 bp[2] End 45,801,452 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva corpus epididymis bronchial epithelial cell epithelium of nasopharynx gingival epithelium Epithelium of choroid plexus gallbladder caput epididymis human penis tibia Top expressed in epithelium of small intestine seminal vesicula conjunctival fornix interventricular septum lobe of prostate migratory enteric neural crest cell vestibular sensory epithelium calvaria submandibular gland gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding clathrin binding cadherin binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol Golgi apparatus membrane intracellular membrane-bounded organelle clathrin-coated vesicle cytoplasmic vesicle nucleoplasm Biological process endocytosis vesicle-mediated transport clathrin coat assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9685 216705 Ensembl ENSG00000113282 ENSMUSG00000006169 UniProt Q14677 Q99KN9 RefSeq (mRNA) NM_001195555 NM_001195556 NM_014666 NM_001045520 NM_001346760 NM_001363484 RefSeq (protein) NP_001182484 NP_001182485 NP_055481 n/a Location (UCSC) Chr 5: 157.79 – 157.86 Mb Chr 11: 45.74 – 45.8 Mb PubMed search [3] [4]
Wikidata
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Function

The CLINT1 protein binds to the terminal domain of the clathrin heavy chain and stimulates clathrin cage vesicle assembly. Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal membranes and across the membranes of other types of cells. This enables a turnover of neuroreceptors or other proteins to be maintained and thus the numbers of receptors can be fine tuned.^[6]

Clinical significance

The CLINT1 gene has been shown to be involved in the genetic aetiology of schizophrenia in four studies ^{[8][9][10][11][12]} It is known that the antipsychotic drugs chlorpromazine and clozapine stabilise clathrin coated vesicles^[13][14] and this may be one reason why antipsychotic drugs are effective in treating delusions, auditory hallucinations and many of the other symptoms of schizophrenia.

Interactions

CLINT1 has been shown to interact with GGA2.^[6][7]