GIT2

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.^[5][6][7]

GIT2
Identifiers
Aliases	GIT2, CAT-2, CAT2, PKL, GIT ArfGAP 2
External IDs	OMIM: 608564; MGI: 1347053; HomoloGene: 41336; GeneCards: GIT2; OMA:GIT2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 109,929,804 bp[1] End 109,996,389 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 114,727,407 bp[2] End 114,775,517 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte middle temporal gyrus Brodmann area 23 granulocyte right hemisphere of cerebellum blood body of pancreas visceral pleura spleen bone marrow Top expressed in primary oocyte thymus granulocyte internal carotid artery secondary oocyte zygote Rostral migratory stream external carotid artery cumulus cell endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity Cellular component focal adhesion nucleoplasm Biological process positive regulation of GTPase activity regulation of G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9815 26431 Ensembl ENSG00000139436 ENSMUSG00000041890 UniProt Q14161 Q9JLQ2 RefSeq (mRNA) NM_001135213 NM_001135214 NM_014776 NM_057169 NM_057170 NM_139201 NM_001330153 NM_001330154 NM_001077359 NM_001077360 NM_019834 NM_001347400 RefSeq (protein) NP_001128685 NP_001128686 NP_001317082 NP_001317083 NP_055591 NP_476510 NP_476511 NP_631940 NP_001070827 NP_001070828 NP_001334329 NP_062808 Location (UCSC) Chr 12: 109.93 – 110 Mb Chr 5: 114.73 – 114.78 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length sequence has been determined for only four variants. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.^[7]

Interactions

GIT2 has been shown to interact with GIT1.^[8]