GIT1

ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.^[5][6][7]

GIT1
Identifiers
Aliases	GIT1, GIT ArfGAP 1, p95-APP1
External IDs	OMIM: 608434; MGI: 1927140; HomoloGene: 32204; GeneCards: GIT1; OMA:GIT1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 29,573,475 bp[1] End 29,594,054 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 77,384,388 bp[2] End 77,398,612 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe cingulate gyrus anterior cingulate cortex olfactory bulb left testis Amygdala prefrontal cortex cerebellar vermis putamen right testis Top expressed in superior frontal gyrus primary visual cortex perirhinal cortex entorhinal cortex dentate gyrus of hippocampal formation granule cell CA3 field ankle joint seminiferous tubule spermatid hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding protein binding metal ion binding GTPase activator activity Cellular component membrane focal adhesion cytoplasm cytosol calyx of Held Biological process ephrin receptor signaling pathway positive regulation of GTPase activity regulation of cytokinesis regulation of G protein-coupled receptor signaling pathway presynaptic modulation of chemical synaptic transmission regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28964 216963 Ensembl ENSG00000108262 ENSMUSG00000011877 UniProt Q9Y2X7 Q68FF6 RefSeq (mRNA) NM_001085454 NM_014030 NM_001004144 NM_001374758 RefSeq (protein) NP_001078923 NP_054749 NP_001004144 NP_001361687 Location (UCSC) Chr 17: 29.57 – 29.59 Mb Chr 11: 77.38 – 77.4 Mb PubMed search [3] [4]
Wikidata
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GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting domain. The Arf-GAP domain, which enables it to act as a GTPase activating protein (GAP) for the Arf family of GTPases, has been shown to be involved in phosphorylation and inhibition of the ADRB2. If synaptic localization of GIT1 is disturbed, then this is known to affect dendritic spine morphology and formation—this is thought to occur through the Rac1/PAK1/LIMK/CFL1 pathway.^[8]

Interactions

GIT1 has been shown to interact with:

• ARHGEF7,^[9][10]
• Beta adrenergic receptor kinase,^[5][6]
• GIT2,^[9]
• PCLO,^[9]
• PLCG1,^[11]
• PPFIA4^[12][13]
• PTK2,^[9][12][14] and
• liprin-alpha-1.^[12][13]