GNB5

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene.^[5] Alternatively spliced transcript variants encoding different isoforms exist.^[6]

GNB5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PBI
Identifiers
Aliases	GNB5, guanine nucleotide binding protein (G protein), beta 5, GB5, G protein subunit beta 5, LADCI, IDDCA, gbeta5, HG2E
External IDs	OMIM: 604447; MGI: 101848; HomoloGene: 40714; GeneCards: GNB5; OMA:GNB5 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 52,115,100 bp[1] End 52,191,392 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 42.3 cM Start 75,213,570 bp[2] End 75,253,158 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus endothelial cell cerebellar hemisphere Brodmann area 23 right hemisphere of cerebellum left ovary lateral nuclear group of thalamus primary visual cortex Pons kidney tubule Top expressed in neural layer of retina retinal pigment epithelium olfactory tubercle superior frontal gyrus cingulate gyrus globus pallidus nucleus accumbens cerebellar cortex dentate gyrus of hippocampal formation granule cell cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein gamma-subunit binding chaperone binding protein binding signal transducer activity GTPase activity GTPase activator activity Cellular component membrane cytosol GTPase activator complex photoreceptor outer segment photoreceptor inner segment nucleus plasma membrane myelin sheath presynapse Biological process positive regulation of GTPase activity negative regulation of voltage-gated calcium channel activity signal transduction protein folding dopamine receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10681 14697 Ensembl ENSG00000069966 ENSMUSG00000032192 UniProt O14775 P62881 RefSeq (mRNA) NM_006578 NM_016194 NM_001379343 NM_010313 NM_138719 RefSeq (protein) NP_006569 NP_057278 NP_001366272 NP_006569.1 NP_034443 NP_619733 Location (UCSC) Chr 15: 52.12 – 52.19 Mb Chr 9: 75.21 – 75.25 Mb PubMed search [3] [4]
Wikidata
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Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.^[6]

GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.^[7]

Interactions

GNB5 has been shown to interact with:

• GNG7,^[8]
• GNG13,^[9]
• RGS7^[10][11] and
• RGS9.^[7]