RGS7

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.^[5][6]

RGS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A72, 2D9J
Identifiers
Aliases	RGS7, regulator of G protein signaling 7
External IDs	OMIM: 602517; MGI: 1346089; HomoloGene: 2193; GeneCards: RGS7; OMA:RGS7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q43|1q23.1 Start 240,767,636 bp[1] End 241,357,374 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 81.11 cM Start 174,886,653 bp[2] End 175,320,066 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus frontal pole Region I of hippocampus proper orbitofrontal cortex Brodmann area 46 Brodmann area 10 primary visual cortex paraflocculus of cerebellum Top expressed in facial motor nucleus primary visual cortex dentate gyrus of hippocampal formation granule cell Cortex of frontal lobe superior frontal gyrus prefrontal cortex temporal lobe primary motor cortex cingulate gyrus Amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein beta-subunit binding GTPase activator activity GTPase activity Cellular component cytosol membrane cytoplasm plasma membrane heterotrimeric G-protein complex Biological process G protein-coupled receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction intracellular signal transduction protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6000 24012 Ensembl ENSG00000182901 ENSMUSG00000026527 UniProt P49802 O54829 RefSeq (mRNA) NM_001282773 NM_001282775 NM_001282778 NM_002924 NM_001350113 NM_001350114 NM_001350115 NM_001350116 NM_001364886 NM_001374806 NM_001374807 NM_001374808 NM_001374809 NM_001374810 NM_001374811 NM_001374812 NM_001374813 NM_001374814 NM_001374815 NM_001374816 NM_001199003 NM_011880 NM_001347195 NM_001357129 RefSeq (protein) NP_001269702 NP_001269704 NP_001269707 NP_002915 NP_001337042 NP_001337043 NP_001337044 NP_001337045 NP_001351815 NP_001361735 NP_001361736 NP_001361737 NP_001361738 NP_001361739 NP_001361740 NP_001361741 NP_001361742 NP_001361743 NP_001361744 NP_001361745 NP_001185932 NP_001334124 NP_036010 NP_001344058 Location (UCSC) Chr 1: 240.77 – 241.36 Mb Chr 1: 174.89 – 175.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.^[7]

Interactions

RGS7 has been shown to interact with:

• GNB5,^[8][9]
• GPR158,^[10]
• GPR179,^[10]
• PKD1,^[11] and
• SNAPAP.^[12]