GNGT1

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.^[5][6] Either GNGT1 or GNGT2 is the gamma subunit (G_γ) of the G_βγ part of transducin (written G(T) or G_t), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cells. GNGT1 only occurs in rod cells, and GNGT2 only occurs in cone cells, with a different alpha (G_α) subunit.^[7][8]

GNGT1
Identifiers
Aliases	GNGT1, GNG1, G protein subunit gamma transducin 1, HG3G1
External IDs	OMIM: 189970; MGI: 109165; HomoloGene: 7738; GeneCards: GNGT1; OMA:GNGT1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 93,591,573 bp[1] End 93,911,265 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 3,993,792 bp[2] End 3,997,436 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium buccal mucosa cell testicle gonad placenta paraflocculus of cerebellum amniotic fluid Epithelium of choroid plexus monocyte thymus Top expressed in neural layer of retina retinal pigment epithelium epithelium of lens pineal gland lumbar subsegment of spinal cord lumbar spinal ganglion ciliary body iris internal carotid artery external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity GTPase activity G-protein beta-subunit binding Cellular component photoreceptor inner segment membrane photoreceptor outer segment photoreceptor disc membrane heterotrimeric G-protein complex plasma membrane G-protein beta/gamma-subunit complex Biological process phototransduction protein localization cardiac muscle cell apoptotic process cellular response to hypoxia rhodopsin mediated signaling pathway eye photoreceptor cell development signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2792 14699 Ensembl ENSG00000127928 ENSMUSG00000029663 UniProt P63211 Q61012 RefSeq (mRNA) NM_021955 NM_001329426 NM_010314 RefSeq (protein) NP_001316355 NP_068774 NP_034444 Location (UCSC) Chr 7: 93.59 – 93.91 Mb Chr 6: 3.99 – 4 Mb PubMed search [3] [4]
Wikidata
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