Golgin subfamily A member 2

Golgin subfamily A member 2, also known as 130 kDa cis-Golgi matrix protein 1 (GM130) is a protein that in humans is encoded by the GOLGA2 gene.^[5]

GOLGA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4REY
Identifiers
Aliases	GOLGA2, GM130, golgin A2
External IDs	OMIM: 602580; MGI: 2139395; HomoloGene: 3300; GeneCards: GOLGA2; OMA:GOLGA2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,255,829 bp[1] End 128,275,995 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 32,177,396 bp[2] End 32,197,933 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary stromal cell of endometrium sural nerve Achilles tendon nipple canal of the cervix pylorus cardia ectocervix Top expressed in zygote vestibular membrane of cochlear duct secondary oocyte internal carotid artery lip external carotid artery primary oocyte muscle of thigh lacrimal gland granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding importin-alpha family protein binding protein binding syntaxin binding protein kinase binding cadherin binding identical protein binding Cellular component cytoplasm Golgi apparatus spindle pole membrane Golgi membrane cis-Golgi network Golgi cis cisterna Golgi cisterna membrane COPII-coated ER to Golgi transport vesicle mitotic spindle microtubule endoplasmic reticulum-Golgi intermediate compartment membrane cytoskeleton Biological process positive regulation of protein glycosylation negative regulation of protein binding cell division spindle assembly protein glycosylation endoplasmic reticulum to Golgi vesicle-mediated transport mitotic spindle assembly COPII vesicle coating asymmetric cell division cell cycle Golgi disassembly negative regulation of autophagy protein homotetramerization Golgi ribbon formation microtubule nucleation meiotic spindle assembly positive regulation of ubiquitin protein ligase activity centrosome cycle Golgi organization protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2801 99412 Ensembl ENSG00000167110 ENSMUSG00000002546 UniProt Q08379 Q921M4 RefSeq (mRNA) NM_004486 NM_001366244 NM_001366246 NM_001080968 NM_133852 NM_001362695 NM_001362696 NM_001362697 NM_001362698 RefSeq (protein) NP_004477 NP_001353173 NP_001353175 NP_001074437 NP_598613 NP_001349624 NP_001349625 NP_001349626 NP_001349627 Location (UCSC) Chr 9: 128.26 – 128.28 Mb Chr 2: 32.18 – 32.2 Mb PubMed search [3] [4]
Wikidata
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Function

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis.^[6] The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.^[7]

A patient with a neuromuscular disorder has been identified that is homozygous for a deletion mutation in this gene, and morpholino knockdown in zebrafish has shown similar phenotypes.^[8]

Interactions

GOLGA2 has been shown to interact with:

• GORASP1,^{[9][10][11][12]}
• GORASP2,^[9][10][11]
• RAB1A,^[9][13][14]
• RAB1B^[15] and
• RAB2A.^[9][16]
• WAC protein^[17]