RAB2A

Ras-related protein Rab-2A is a protein that in humans is encoded by the RAB2A gene.^[5]

RAB2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z0A
Identifiers
Aliases	RAB2A, LHX, RAB2, member RAS oncogene family
External IDs	OMIM: 179509; MGI: 1928750; HomoloGene: 20628; GeneCards: RAB2A; OMA:RAB2A - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.1-q12.2 Start 60,516,936 bp[1] End 60,623,644 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A1 Start 8,535,644 bp[2] End 8,607,778 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii parotid gland pons right ventricle postcentral gyrus islet of Langerhans Skeletal muscle tissue of rectus abdominis entorhinal cortex superior frontal gyrus stromal cell of endometrium Top expressed in dorsomedial hypothalamic nucleus ventral tegmental area piriform cortex paraventricular nucleus of hypothalamus habenula cerebellar vermis Region I of hippocampus proper ventromedial nucleus superior colliculus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding protein binding GTPase activity Cellular component endoplasmic reticulum membrane membrane melanosome Golgi membrane lysosomal membrane endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment membrane extracellular exosome nucleus cytosol Golgi apparatus intracellular anatomical structure Biological process Golgi organization endoplasmic reticulum to Golgi vesicle-mediated transport protein transport vesicle-mediated transport post-translational protein modification transport intracellular protein transport Rab protein signal transduction small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5862 59021 Ensembl ENSG00000104388 ENSMUSG00000047187 UniProt P61019 P53994 RefSeq (mRNA) NM_002865 NM_001242644 NM_021518 RefSeq (protein) NP_001229573 NP_002856 NP_067493 Location (UCSC) Chr 8: 60.52 – 60.62 Mb Chr 4: 8.54 – 8.61 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM]^[5]

Interactions

RAB2A has been shown to interact with GOLGA2.^[6][7]