GPAA1

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.^[5][6]

GPAA1
Identifiers
Aliases	GPAA1, GAA1, hGAA1, glycosylphosphatidylinositol anchor attachment 1, GPIBD15
External IDs	OMIM: 603048; MGI: 1202392; HomoloGene: 37852; GeneCards: GPAA1; OMA:GPAA1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,082,590 bp[1] End 144,086,216 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,215,431 bp[2] End 76,219,107 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right lobe of thyroid gland apex of heart left lobe of thyroid gland right adrenal gland left adrenal gland right adrenal cortex mucosa of transverse colon left adrenal cortex body of stomach Top expressed in right kidney lip granulocyte neural layer of retina muscle of thigh yolk sac primary visual cortex superior frontal gyrus ventricular zone proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tubulin binding GPI-anchor transamidase activity GPI anchor binding protein binding Cellular component integral component of membrane endoplasmic reticulum membrane GPI-anchor transamidase complex endoplasmic reticulum membrane Biological process protein retention in ER lumen GPI anchor biosynthetic process attachment of GPI anchor to protein protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8733 14731 Ensembl ENSG00000197858 ENSMUSG00000022561 UniProt O43292 Q9WTK3 RefSeq (mRNA) NM_003801 NM_010331 RefSeq (protein) NP_003792 NP_034461 Location (UCSC) Chr 8: 144.08 – 144.09 Mb Chr 15: 76.22 – 76.22 Mb PubMed search [3] [4]
Wikidata
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Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.^[6]

Interactions

GPAA1 has been shown to interact with PIGT^[7][8] and PIGK.^[8][9]