PIGK

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.^[5][6]

PIGK
Identifiers
Aliases	PIGK, GPI8, phosphatidylinositol glycan anchor biosynthesis class K, NEDHCAS
External IDs	OMIM: 605087; MGI: 1913863; HomoloGene: 4002; GeneCards: PIGK; OMA:PIGK - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 77,088,989 bp[1] End 77,219,430 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H3 Start 152,714,100 bp[2] End 152,980,408 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Achilles tendon stromal cell of endometrium islet of Langerhans retinal pigment epithelium right coronary artery right ventricle kidney tubule glomerulus popliteal artery Top expressed in spermatocyte spermatid cingulate gyrus Ileal epithelium extensor digitorum longus muscle cardiac muscle tissue of left ventricle plantaris muscle supraoptic nucleus calvaria decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GPI-anchor transamidase activity peptidase activity cysteine-type peptidase activity GPI anchor binding protein binding hydrolase activity protein disulfide isomerase activity Cellular component integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane membrane GPI-anchor transamidase complex endoplasmic reticulum Biological process GPI anchor biosynthetic process attachment of GPI anchor to protein protein localization to cell surface proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10026 329777 Ensembl ENSG00000142892 ENSMUSG00000039047 UniProt Q92643 Q9CXY9 RefSeq (mRNA) NM_005482 NM_025662 NM_178016 RefSeq (protein) NP_005473 NP_079938 NP_821135 Location (UCSC) Chr 1: 77.09 – 77.22 Mb Chr 3: 152.71 – 152.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.^[6]

Interactions

PIGK has been shown to interact with PIGT^[7] and GPAA1.^[8][9]