GPR112

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene.^[5][6] GPR112 is a member of the adhesion GPCR family.^[7][8] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[9]

ADGRG4
Identifiers
Aliases	ADGRG4, PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4
External IDs	MGI: 2685213; HomoloGene: 72131; GeneCards: ADGRG4; OMA:ADGRG4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 136,300,963 bp[1] End 136,416,890 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A6 Start 55,915,523 bp[2] End 56,046,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum jejunal mucosa left uterine tube gastric mucosa Achilles tendon urinary bladder body of uterus right coronary artery fundus tibial arteries Top expressed in proximal tubule secondary oocyte primary oocyte zygote right kidney human kidney embryo duodenum jejunum placenta More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane membrane intracellular anatomical structure integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 139378 236798 Ensembl ENSG00000156920 ENSMUSG00000053852 UniProt Q8IZF6 n/a RefSeq (mRNA) NM_153834 NM_001033327 NM_001110790 NM_001362885 RefSeq (protein) NP_722576 n/a Location (UCSC) Chr X: 136.3 – 136.42 Mb Chr X: 55.92 – 56.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GPR112 is expressed in human enterochromaffin cells^[10] and in the mouse intestine.^[11] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.^[11] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.^[10]