GPR123

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene.^[5][6] It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7][8][9]

ADGRA1
Identifiers
Aliases	ADGRA1, GPR123, adhesion G protein-coupled receptor A1
External IDs	OMIM: 612302; MGI: 1277167; HomoloGene: 18582; GeneCards: ADGRA1; OMA:ADGRA1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,087,924 bp[1] End 133,131,675 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F4|7 84.89 cM Start 139,414,090 bp[2] End 139,458,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex prefrontal cortex hypothalamus lateral nuclear group of thalamus primary visual cortex amygdala ventricular zone Top expressed in facial motor nucleus lumbar subsegment of spinal cord medial dorsal nucleus Rostral migratory stream substantia nigra lateral geniculate nucleus medial geniculate nucleus subiculum dentate gyrus of hippocampal formation granule cell amygdala More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane membrane postsynaptic density glutamatergic synapse Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84435 52389 Ensembl ENSG00000197177 ENSMUSG00000025475 UniProt Q86SQ6 Q8C4G9 RefSeq (mRNA) NM_001083909 NM_001291085 NM_032422 NM_177469 RefSeq (protein) NP_001077378 NP_001278014 NP_803420 Location (UCSC) Chr 10: 133.09 – 133.13 Mb Chr 7: 139.41 – 139.46 Mb PubMed search [3] [4]
Wikidata
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