GPR124

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.^[5][6][7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[8][9][10]

ADGRA2
Identifiers
Aliases	ADGRA2, G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2
External IDs	OMIM: 606823; MGI: 1925810; HomoloGene: 13112; GeneCards: ADGRA2; OMA:ADGRA2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 37,784,191 bp[1] End 37,844,896 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 27,575,611 bp[2] End 27,613,464 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium seminal vesicula canal of the cervix left uterine tube saphenous vein body of uterus gallbladder right ovary tail of epididymis superficial temporal artery Top expressed in umbilical cord dermis external carotid artery Gonadal ridge yolk sac endocardial cushion internal carotid artery vas deferens uterus abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity protein binding signal transducer activity transmembrane signaling receptor activity Cellular component integral component of membrane cell surface plasma membrane membrane cell projection filopodium Biological process positive regulation of endothelial cell migration G protein-coupled receptor signaling pathway cell surface receptor signaling pathway central nervous system development negative regulation of vascular endothelial growth factor signaling pathway sprouting angiogenesis regulation of angiogenesis endothelial cell migration regulation of chemotaxis angiogenesis signal transduction regulation of establishment of blood-brain barrier Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25960 78560 Ensembl ENSG00000020181 ENSMUSG00000031486 UniProt Q96PE1 Q91ZV8 RefSeq (mRNA) NM_032777 NM_054044 RefSeq (protein) NP_116166 NP_473385 Location (UCSC) Chr 8: 37.78 – 37.84 Mb Chr 8: 27.58 – 27.61 Mb PubMed search [3] [4]
Wikidata
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Interactions

GPR124 has been shown to interact with DLG1^[11] and is involved in the Wnt/β-catenin signaling pathway along with RECK.^[12] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain.^[13] GPR124 (ADGRA2) was predicted using SSHHPS.

Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.