GPR133

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.^[5][6]

ADGRD1
Identifiers
Aliases	ADGRD1, PGR25, GPR133, adhesion G protein-coupled receptor D1
External IDs	OMIM: 613639; MGI: 3041203; HomoloGene: 34616; GeneCards: ADGRD1; OMA:ADGRD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 130,953,907 bp[1] End 131,141,469 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,173,814 bp[2] End 129,281,663 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium right auricle of heart tibial nerve decidua right lung sural nerve upper lobe of left lung myocardium of left ventricle gastric mucosa apex of heart Top expressed in lumbar spinal ganglion Ileal epithelium lactiferous gland ankle joint extraocular muscle white adipose tissue body of femur sciatic nerve ascending aorta thoracic diaphragm More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane intracellular anatomical structure integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283383 243277 Ensembl ENSG00000111452 ENSMUSG00000044017 UniProt Q6QNK2 Q80T32 RefSeq (mRNA) NM_198827 NM_001330497 NM_001081342 NM_177734 NM_001347486 RefSeq (protein) NP_001317426 NP_942122 NP_001074811 NP_001334415 Location (UCSC) Chr 12: 130.95 – 131.14 Mb Chr 5: 129.17 – 129.28 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7][8]

GPR133 binds androgens, specifically the androgen 5α-dihydrotestosterone (5α-DHT).^[9] GPR133 is an adhesion G protein-coupled receptor that functions as a membrane receptor for androgens. When activated by 5α-DHT, GPR133 increases intracellular cyclic AMP (cAMP) levels in muscle cells, leading to enhanced muscle strength.^[9]