GRB7

Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.^[5][6]

GRB7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PQZ, 1MW4, 1WGR, 2L4K, 2QMS, 4WWQ, 4X6S, 5EEL, 5EEQ, 5D0J
Identifiers
Aliases	GRB7, entrez:2886, growth factor receptor bound protein 7
External IDs	OMIM: 601522; MGI: 102683; HomoloGene: 3881; GeneCards: GRB7; OMA:GRB7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 39,737,927 bp[1] End 39,747,291 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.75 cM Start 98,337,220 bp[2] End 98,346,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right uterine tube body of pancreas skin of abdomen skin of leg minor salivary glands olfactory zone of nasal mucosa right lobe of liver mucosa of transverse colon Top expressed in Ileal epithelium right kidney genital tubercle proximal tubule corneal stroma nasolacrimal duct transitional epithelium of urinary bladder yolk sac left lobe of liver tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatidylinositol binding identical protein binding RNA binding protein kinase binding lipid binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion plasma membrane cell junction cytoplasmic stress granule Biological process negative regulation of translation epidermal growth factor receptor signaling pathway positive regulation of cell migration leukocyte migration signal transduction stress granule assembly ERBB2 signaling pathway positive regulation of signal transduction axon guidance insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2886 14786 Ensembl ENSG00000141738 ENSMUSG00000019312 UniProt Q14451 Q03160 RefSeq (mRNA) NM_001030002 NM_001242442 NM_001242443 NM_005310 NM_001330207 NM_010346 RefSeq (protein) NP_001025173 NP_001229371 NP_001229372 NP_001317136 NP_005301 NP_034476 Location (UCSC) Chr 17: 39.74 – 39.75 Mb Chr 11: 98.34 – 98.35 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.^[5]

Clinical significance

GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene.

These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7, thought to be involved in migration,^[5] is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.

Interactions

GRB7 has been shown to interact with:

• EPH receptor B1,^[7]
• Insulin receptor,^[8]
• PTK2,^[9]
• RET proto-oncogene,^[10] and
• Rnd1^[11]