Rnd1

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.^[5] It is encoded by the gene RND1.^[6]

RND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CLS, 2REX, 3Q3J
Identifiers
Aliases	RND1, ARHS, RHO6, RHOS, Rnd1, Rho family GTPase 1
External IDs	OMIM: 609038; MGI: 2444878; HomoloGene: 8706; GeneCards: RND1; OMA:RND1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,857,145 bp[1] End 48,865,870 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 98,561,302 bp[2] End 98,575,342 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava right lobe of liver frontal pole prefrontal cortex right frontal lobe middle temporal gyrus dorsolateral prefrontal cortex primary visual cortex Brodmann area 9 cingulate gyrus Top expressed in lumbar subsegment of spinal cord granulocyte primary visual cortex morula ventricular zone cerebellar cortex superior frontal gyrus endothelial cell of lymphatic vessel neural layer of retina dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding signaling receptor binding protein binding GTPase activity protein kinase binding Cellular component cytoplasm adherens junction cytosol cytoskeleton membrane plasma membrane actin cytoskeleton intracellular membrane-bounded organelle intracellular anatomical structure cell cortex cell division site Biological process neuron remodeling small GTPase mediated signal transduction negative regulation of cell adhesion actin filament organization Rho protein signal transduction regulation of cell shape regulation of cell migration establishment or maintenance of actin cytoskeleton polarity regulation of actin cytoskeleton organization actin filament bundle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27289 223881 Ensembl ENSG00000172602 ENSMUSG00000054855 UniProt Q92730 Q8BLR7 RefSeq (mRNA) NM_014470 NM_172612 RefSeq (protein) NP_055285 NP_766200 Location (UCSC) Chr 12: 48.86 – 48.87 Mb Chr 15: 98.56 – 98.58 Mb PubMed search [3] [4]
Wikidata
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It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]^[6]

Interactions

Rnd1 has been shown to interact with GRB7,^[7] PLXNB1,^[8] PDE6D,^[9][10] ARHGAP5^[11] and UBXD5.^[12]