GTF2A1

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.^[5][6]

GTF2A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NVP, 5IYB, 5IYC, 5IY9, 5IY8, 5IY7, 5IYD, 5IY6, 5FUR, 5IYA
Identifiers
Aliases	GTF2A1, TF2A1, TFIIA, TFIIA-42, TFIIAL, general transcription factor IIA subunit 1
External IDs	OMIM: 600520; MGI: 1933277; HomoloGene: 56331; GeneCards: GTF2A1; OMA:GTF2A1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q31.1 Start 81,175,452 bp[1] End 81,221,377 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 D3|12 Start 91,522,036 bp[2] End 91,557,261 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia corpus epididymis pons trabecular bone jejunal mucosa oral cavity postcentral gyrus caput epididymis Achilles tendon tendon of biceps brachii Top expressed in zygote secondary oocyte retinal pigment epithelium spermatocyte genital tubercle spermatid ascending aorta aortic valve tail of embryo primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function TBP-class protein binding DNA binding transcription coactivator activity transcription factor binding protein binding protein heterodimerization activity RNA polymerase II general transcription initiation factor activity Cellular component transcription factor TFIIA complex nucleus nucleoplasm transcription factor TFIID complex cytosol cytoplasm Biological process transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated snRNA transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2957 83602 Ensembl ENSG00000165417 ENSMUSG00000020962 UniProt P52655 Q99PM3 RefSeq (mRNA) NM_201595 NM_001278940 NM_015859 NM_031391 NM_175335 RefSeq (protein) NP_001265869 NP_056943 NP_963889 NP_113568 NP_780544 Location (UCSC) Chr 14: 81.18 – 81.22 Mb Chr 12: 91.52 – 91.56 Mb PubMed search [3] [4]
Wikidata
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Interactions

GTF2A1 has been shown to interact with TATA binding protein^{[7][8][9][10][11]} and TBPL1.^[12][13]

See also

• Transcription Factor II A