TBPL1

TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.^[5][6][7][8]

TBPL1
Identifiers
Aliases	TBPL1, MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2, TATA-box binding protein like 1
External IDs	OMIM: 605521; MGI: 1339946; HomoloGene: 3577; GeneCards: TBPL1; OMA:TBPL1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 133,952,170 bp[1] End 133,990,432 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A3 Start 22,579,778 bp[2] End 22,607,837 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte left testis right testis sperm ganglionic eminence gonad prefrontal cortex Brodmann area 9 middle temporal gyrus Top expressed in spermatid spermatocyte seminiferous tubule medial ganglionic eminence tail of embryo superior cervical ganglion neural tube ventricular zone seminal vesicula granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase III transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity transcription factor binding Cellular component cytoplasm transcription factor TFIIA complex nucleus transcription factor TFIIIB complex transcription regulator complex transcription factor TFIID complex Biological process spermatid nucleus differentiation regulation of transcription, DNA-templated transcription by RNA polymerase II acrosome assembly dTTP biosynthetic process transcription, DNA-templated spermatogenesis DNA-templated transcription, initiation positive regulation of transcription by RNA polymerase II RNA polymerase III preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9519 237336 Ensembl ENSG00000028839 ENSMUSG00000071359 UniProt P62380 Q7Z6T9 P62340 RefSeq (mRNA) NM_004865 NM_001253676 NM_011603 RefSeq (protein) NP_001240605 NP_004856 NP_035733 Location (UCSC) Chr 6: 133.95 – 133.99 Mb Chr 10: 22.58 – 22.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.^[8]

Interactions

TBPL1 has been shown to interact with GTF2A1.^[9][10]