GTF2H1

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.^[5][6][7]

GTF2H1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PFJ, 2DII, 2RNR, 2RUK, 2RVB
Identifiers
Aliases	GTF2H1, BTF2, P62, TFB1, TFIIH, general transcription factor IIH subunit 1
External IDs	OMIM: 189972; MGI: 1277216; HomoloGene: 3885; GeneCards: GTF2H1; OMA:GTF2H1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 18,322,295 bp[1] End 18,367,045 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 46,445,527 bp[2] End 46,473,224 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum endometrium tonsil right testis left testis monocyte islet of Langerhans smooth muscle tissue gallbladder Top expressed in spermatocyte spermatid yolk sac Rostral migratory stream lacrimal gland genital tubercle neural layer of retina epiblast morula endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity ATP-dependent activity, acting on DNA chromatin binding protein binding RNA polymerase II CTD heptapeptide repeat kinase activity Cellular component nucleoplasm transcription factor TFIIH holo complex nucleus transcription factor TFIIH core complex Biological process termination of RNA polymerase I transcription regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription, DNA-templated transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription, DNA-templated cellular response to DNA damage stimulus global genome nucleotide-excision repair transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter nucleotide-excision repair, DNA incision DNA repair positive regulation of transcription by RNA polymerase II nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, preincision complex assembly transcription by RNA polymerase I phosphorylation of RNA polymerase II C-terminal domain nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 3'-to lesion transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2965 14884 Ensembl ENSG00000110768 ENSG00000288114 ENSMUSG00000006599 UniProt P32780 Q9DBA9 RefSeq (mRNA) NM_001142307 NM_005316 NM_001291075 NM_008186 NM_001360075 NM_001360076 RefSeq (protein) NP_001135779 NP_005307 NP_001278004 NP_032212 NP_001347004 NP_001347005 Location (UCSC) Chr 11: 18.32 – 18.37 Mb Chr 7: 46.45 – 46.47 Mb PubMed search [3] [4]
Wikidata
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Interactions

GTF2H1 has been shown to interact with:

• Cyclin-dependent kinase 7,^[8][9][10]
• E2F1,^[11]
• ERCC2,^[8][12]
• Estrogen receptor alpha,^[13]
• TCEA1,^[14][15] and
• XPB.^[8][16][17]

See also

• Transcription Factor II H