TCEA1

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.^[5][6][7]

TCEA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TFI, 3NDQ, 5IY7, 5IYA, 5IY6, 5IYB, 5IY8, 5IYC
Identifiers
Aliases	TCEA1, GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1
External IDs	OMIM: 601425; MGI: 1196624; HomoloGene: 55984; GeneCards: TCEA1; OMA:TCEA1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q11.23 Start 53,966,552 bp[1] End 54,022,456 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A1 Start 4,928,037 bp[2] End 4,968,132 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone Achilles tendon optic nerve caput epididymis cartilage tissue tail of epididymis corpus epididymis skin of thigh parotid gland lactiferous duct Top expressed in zygote fetal liver hematopoietic progenitor cell tail of embryo secondary oocyte medial ganglionic eminence parotid gland lacrimal gland hand calvaria human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding protein binding metal ion binding nucleic acid binding Cellular component nucleolus nucleus nucleoplasm transcription factor TFIID complex Biological process transcription elongation from RNA polymerase II promoter transcription-coupled nucleotide-excision repair regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of exoribonuclease activity positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6917 21399 Ensembl ENSG00000187735 ENSMUSG00000033813 UniProt P23193 P10711 RefSeq (mRNA) NM_006756 NM_201437 NM_001159750 NM_001159751 NM_011541 RefSeq (protein) NP_006747 NP_958845 NP_001153222 NP_001153223 NP_035671 Location (UCSC) Chr 8: 53.97 – 54.02 Mb Chr 1: 4.93 – 4.97 Mb PubMed search [3] [4]
Wikidata
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In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex.^[8] A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.^[9]

Interactions

TCEA1 has been shown to interact with GTF2H1^[10][11] and POLR2A.^[10][11][12]