GTF2H4

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.^[5][6]

GTF2H4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Identifiers
Aliases	GTF2H4, general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
External IDs	OMIM: 601760; MGI: 1338799; HomoloGene: 7090; GeneCards: GTF2H4; OMA:GTF2H4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,908,207 bp[1] End 30,914,106 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,978,622 bp[2] End 35,984,631 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver pituitary gland right hemisphere of cerebellum anterior pituitary left lobe of thyroid gland right lobe of thyroid gland body of uterus tibial arteries right coronary artery apex of heart Top expressed in thymus otic vesicle otic placode spermatocyte epiblast saccule mandibular prominence abdominal wall maxillary prominence ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity ATP-dependent activity, acting on DNA DNA-binding transcription factor activity DNA helicase activity protein binding RNA polymerase II CTD heptapeptide repeat kinase activity double-stranded DNA binding ATPase activator activity RNA polymerase II general transcription initiation factor activity Cellular component nucleoplasm transcription factor TFIIH holo complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH core complex nucleus transcription factor TFIID complex nuclear speck Biological process termination of RNA polymerase I transcription regulation of transcription, DNA-templated phosphorylation of RNA polymerase II C-terminal domain transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription, DNA-templated cellular response to DNA damage stimulus global genome nucleotide-excision repair transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter nucleotide-excision repair, DNA incision DNA repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion DNA duplex unwinding positive regulation of ATP-dependent activity nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 3'-to lesion transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2968 14885 Ensembl ENSG00000213780 ENSMUSG00000001524 UniProt Q92759 O70422 RefSeq (mRNA) NM_001517 NM_010364 RefSeq (protein) NP_001508 NP_034494 Location (UCSC) Chr 6: 30.91 – 30.91 Mb Chr 17: 35.98 – 35.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GTF2H4 has been shown to interact with:

• GTF2F1,^[7]
• MED21,^[7]
• POLR2A,^[7]
• TATA binding protein,^[7]
• Transcription Factor II B,^[7] and
• XPB.^[5][8]

See also

• Transcription Factor II H