MED21

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.^[5][6]

MED21
Identifiers
Aliases	MED21, SRB7, SURB7, hSrb7, mediator complex subunit 21
External IDs	OMIM: 603800; MGI: 1347064; HomoloGene: 3148; GeneCards: MED21; OMA:MED21 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.23 Start 27,022,546 bp[1] End 27,066,343 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G3|6 77.7 cM Start 146,544,045 bp[2] End 146,552,230 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon islet of Langerhans testicle right ventricle muscle of thigh ganglionic eminence popliteal artery tibial arteries gonad Top expressed in zygote right kidney secondary oocyte endocardial cushion interventricular septum tail of embryo atrioventricular valve ventricular zone embryo yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity transcription coactivator activity transcription coregulator activity protein binding ubiquitin protein ligase activity Cellular component nucleus ubiquitin ligase complex mediator complex Biological process regulation of transcription by RNA polymerase II stem cell population maintenance regulation of transcription, DNA-templated protein ubiquitination blastocyst development transcription, DNA-templated positive regulation of transcription by RNA polymerase II RNA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9412 108098 Ensembl ENSG00000152944 ENSMUSG00000030291 UniProt Q13503 Q9CQ39 RefSeq (mRNA) NM_001271811 NM_004264 NM_025315 RefSeq (protein) NP_001258740 NP_004255 NP_079591 Location (UCSC) Chr 12: 27.02 – 27.07 Mb Chr 6: 146.54 – 146.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MED21 has been shown to interact with:

• BRCA1,^[7]
• CDK8,^{[8][9][10][11]}
• GTF2F1,^[7][9]
• GTF2H4,^[7]
• MED6,^[12] and
• POLR2A.^[7][8][9]