HBE1

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.^[5]

HBE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9W
Identifiers
Aliases	HBE1, HBE, hemoglobin subunit epsilon 1
External IDs	OMIM: 142100; MGI: 96024; HomoloGene: 110794; GeneCards: HBE1; OMA:HBE1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,268,345 bp[1] End 5,505,652 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 54.85 cM Start 103,490,844 bp[2] End 103,492,371 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad ganglionic eminence blood monocyte stromal cell of endometrium apex of heart ventricular zone gastrocnemius muscle anterior cingulate cortex Top expressed in abdominal wall yolk sac somite endocardial cushion internal carotid artery maxillary prominence external carotid artery hand mandibular prominence tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function hemoglobin alpha binding metal ion binding heme binding iron ion binding oxygen binding oxygen carrier activity protein binding peroxidase activity haptoglobin binding organic acid binding Cellular component cytosol blood microparticle hemoglobin complex haptoglobin-hemoglobin complex Biological process protein heterooligomerization blood coagulation oxygen transport response to organic cyclic compound transport hydrogen peroxide catabolic process cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3046 15132 Ensembl ENSG00000213931 ENSMUSG00000052217 UniProt P02100 P04444 RefSeq (mRNA) NM_005330 NM_008219 RefSeq (protein) NP_005321 NP_005321.1 NP_032245 Location (UCSC) Chr 11: 5.27 – 5.51 Mb Chr 7: 103.49 – 103.49 Mb PubMed search [3] [4]
Wikidata
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Function

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.^[6]

See also

• Hemoglobin
• Human β-globin locus
• Hemoglobin alpha chains (two genes, same sequence):
  • HBA1
  • HBA2