HCN4

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.^[5][6][7][8]

HCN4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MNG, 3OTF, 3U11, 4HBN, 4KL1, 4NVP
Identifiers
Aliases	HCN4, SSS2, hyperpolarization activated cyclic nucleotide gated potassium channel 4, BRGDA8, EIG18
External IDs	OMIM: 605206; MGI: 1298209; HomoloGene: 3997; GeneCards: HCN4; OMA:HCN4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 73,319,859 bp[1] End 73,368,958 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 58,730,695 bp[2] End 58,770,458 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle right atrium right auricle of heart apex of heart testicle left ventricle secondary oocyte right ventricle gonad mucosa of ileum Top expressed in myocardium cardiac muscles Cardiac muscle tissue of myocardium electrical conduction system of the heart sinus venosus right atrium sinoatrial node septum transversum vein left horn of sinus venosus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding potassium channel activity cAMP binding sodium channel activity voltage-gated ion channel activity ion channel activity intracellular cAMP-activated cation channel activity identical protein binding voltage-gated potassium channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity involved in SA node cell action potential depolarization Cellular component integral component of membrane membrane intrinsic component of plasma membrane plasma membrane perinuclear region of cytoplasm HCN channel complex Biological process cellular response to cGMP muscle contraction sodium ion transmembrane transport sodium ion transport SA node cell action potential regulation of membrane potential regulation of ion transmembrane transport cation transport ion transport blood circulation regulation of membrane depolarization regulation of heart rate potassium ion transport transmembrane transport potassium ion transmembrane transport regulation of cardiac muscle contraction regulation of heart rate by cardiac conduction cellular response to cAMP membrane depolarization during cardiac muscle cell action potential membrane depolarization during SA node cell action potential sodium ion import across plasma membrane regulation of cardiac muscle cell action potential involved in regulation of contraction potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10021 330953 Ensembl ENSG00000138622 ENSMUSG00000032338 UniProt Q9Y3Q4 O70507 RefSeq (mRNA) NM_005477 NM_001081192 RefSeq (protein) NP_005468 NP_001074661 Location (UCSC) Chr 15: 73.32 – 73.37 Mb Chr 9: 58.73 – 58.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart.^[9] Some humans with bradycardia and Sick sinus syndrome have been shown to have mutations in their HCN4 gene.^[10][11][12] The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.^{[13][14][15][16]}

Interactions

HCN4 has been shown to interact with HCN2.^[17]

See also

• Cyclic nucleotide-gated ion channel
• Funny current