Histone deacetylase 5

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.^[5][6][7]

HDAC5
Identifiers
Aliases	HDAC5, HD5, NY-CO-9, histone deacetylase 5
External IDs	OMIM: 605315; MGI: 1333784; HomoloGene: 3995; GeneCards: HDAC5; OMA:HDAC5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,076,746 bp[1] End 44,123,702 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 102,194,432 bp[2] End 102,230,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen ganglionic eminence muscle of thigh right frontal lobe popliteal artery tibial arteries right hemisphere of cerebellum apex of heart gastric mucosa Top expressed in neural layer of retina perirhinal cortex entorhinal cortex CA3 field primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus lip muscle of thigh central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding chromatin binding metal ion binding protein binding hydrolase activity protein kinase C binding histone deacetylase activity transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component Golgi apparatus histone deacetylase complex cytoplasm nucleus nucleoplasm cytosol nuclear speck protein-containing complex Biological process histone H3 deacetylation chromatin remodeling regulation of myotube differentiation regulation of transcription, DNA-templated regulation of gene expression, epigenetic positive regulation of DNA-binding transcription factor activity regulation of histone H3-K9 acetylation response to activity transcription, DNA-templated protein deacetylation negative regulation of cell migration involved in sprouting angiogenesis B cell activation neuron differentiation negative regulation of myotube differentiation cellular response to insulin stimulus B cell differentiation inflammatory response regulation of protein binding negative regulation of transcription, DNA-templated cellular response to lipopolysaccharide positive regulation of transcription by RNA polymerase II response to cocaine negative regulation of transcription by RNA polymerase II histone deacetylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10014 15184 Ensembl ENSG00000108840 ENSMUSG00000008855 UniProt Q9UQL6 Q9Z2V6 RefSeq (mRNA) NM_001015053 NM_005474 NM_139205 NM_001382393 NM_001077696 NM_001284248 NM_001284249 NM_001284250 NM_010412 NM_001361596 RefSeq (protein) NP_001015053 NP_005465 NP_001369322 n/a Location (UCSC) Chr 17: 44.08 – 44.12 Mb Chr 11: 102.19 – 102.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.^[7]

AMP-activated protein kinase regulation of the glucose transporter GLUT4 occurs by phosphorylation of HDAC5.^[8]

HDAC5 is involved in memory consolidation and suggests that development of more selective HDAC inhibitors for the treatment of Alzheimer's disease should avoid targeting HDAC5.^[9] Its function can be effectively examined by siRNA knockdown based on an independent validation.^[10]

HDAC5 overexpression in urothelial carcinoma cell lines inhibits long-term proliferation but can promote epithelial-to-mesenchymal transition (EMT)^[11]

Interactions

Histone deacetylase 5 has been shown to interact with:

• BCL6,^[12]
• CBX5,^[13]
• GATA1,^[14]
• HDAC3,^{[5][15][16][17]}
• IKZF1,^[18]
• MEF2A,^[19]
• NRIP1,^[20]
• NCOR1,^[15][21]
• NCOR2,^[21]
• YWHAQ,^[22] and
• ZBTB16.^[12][23]

See also

• Histone deacetylase