Zinc finger and BTB domain-containing protein 16

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

ZBTB16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BUO, 1CS3
Identifiers
Aliases	ZBTB16, PLZF, ZNF145, zinc finger and BTB domain containing 16
External IDs	OMIM: 176797; MGI: 103222; HomoloGene: 21214; GeneCards: ZBTB16; OMA:ZBTB16 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.2 Start 114,059,041 bp[1] End 114,256,765 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.3|9 26.47 cM Start 48,565,597 bp[2] End 48,747,522 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of hip Brodmann area 23 tibialis anterior muscle Skeletal muscle tissue of rectus abdominis pericardium saphenous vein skin of thigh deltoid muscle biceps brachii Skeletal muscle tissue of biceps brachii Top expressed in extensor digitorum longus muscle plantaris muscle digastric muscle extraocular muscle aortic valve gastrula muscle of thigh ankle thoracic diaphragm soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding protein homodimerization activity DNA-binding transcription factor activity metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding identical protein binding nucleic acid binding double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein C-terminus binding protein domain specific binding sequence-specific DNA binding Cellular component PML body nuclear speck nuclear body plasma membrane transcription repressor complex nucleus cytosol protein-containing complex nucleoplasm Biological process embryonic hindlimb morphogenesis forelimb morphogenesis skeletal system development myeloid cell differentiation regulation of transcription, DNA-templated embryonic pattern specification embryonic digit morphogenesis positive regulation of ossification negative regulation of transcription by RNA polymerase II hindlimb morphogenesis transcription, DNA-templated mesonephros development positive regulation of transcription, DNA-templated central nervous system development cartilage development male germ-line stem cell asymmetric division positive regulation of cartilage development protein ubiquitination positive regulation of chondrocyte differentiation positive regulation of apoptotic process protein localization to nucleus positive regulation of NK T cell differentiation negative regulation of transcription, DNA-templated positive regulation of fat cell differentiation negative regulation of myeloid cell differentiation anterior/posterior pattern specification negative regulation of cell population proliferation apoptotic process post-translational protein modification hemopoiesis positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7704 235320 Ensembl ENSG00000109906 ENSMUSG00000066687 UniProt Q05516 Q3UQ17 RefSeq (mRNA) NM_001018011 NM_006006 NM_001354750 NM_001354751 NM_001354752 NM_001033324 NM_001364543 RefSeq (protein) NP_001018011 NP_005997 NP_001341679 NP_001341680 NP_001341681 NP_001028496 NP_001351472 Location (UCSC) Chr 11: 114.06 – 114.26 Mb Chr 9: 48.57 – 48.75 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)^[5] and physiological roles have been identified in mouse Natural Killer T cells^[6][7] and gamma-delta T cells.^[8] Alternate transcriptional splice variants have been characterized in human.^[9][10]

Interactions

Zinc finger and BTB domain-containing protein 16 has been shown to interact with:

• Angiotensin II receptor type 1,^[11]
• BCL6,^[12]
• BMI1,^[13]
• Calcitriol receptor,^[14][15]
• FHL2,^[16]
• GATA1,^[17]
• GATA2,^[18]
• HDAC1,^[19][20][21]
• HDAC4,^[19][22]
• HDAC5,^[19][22]
• HDAC6,^[19]
• Heparin-binding EGF-like growth factor,^[23][24]
• Nuclear receptor co-repressor 2,^[21][25][26]
• Promyelocytic leukemia protein^[27]
• RUNX1T1,^[28][29]
• Retinoic acid receptor alpha,^[30]
• SIN3A,^[14][20][21]
• SIN3B,^[20] and
• ZBTB32.^[31]

See also

• Zbtb7