HES6

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.^[5][6]

HES6
Identifiers
Aliases	HES6, C-HAIRY1, HES-6, bHLHb41, bHLHc23, hes family bHLH transcription factor 6
External IDs	OMIM: 610331; MGI: 1859852; HomoloGene: 23111; GeneCards: HES6; OMA:HES6 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 238,238,267 bp[1] End 238,240,662 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 91,339,205 bp[2] End 91,341,760 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone secondary oocyte C1 segment mucosa of transverse colon anterior pituitary Brodmann area 9 primary visual cortex cingulate gyrus anterior cingulate cortex Top expressed in ventricular zone fossa right kidney internal carotid artery adrenal gland saccule ganglionic eminence left lobe of liver Paneth cell proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein dimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription coregulator activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component nucleus transcription regulator complex Biological process regulation of transcription by RNA polymerase II multicellular organism development cell differentiation negative regulation of transcription by RNA polymerase II transcription, DNA-templated nervous system development regulation of transcription, DNA-templated somitogenesis Notch signaling pathway regulation of neurogenesis anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55502 55927 Ensembl ENSG00000144485 ENSMUSG00000067071 UniProt Q96HZ4 Q9JHE6 RefSeq (mRNA) NM_018645 NM_001142853 NM_001282434 NM_019479 NM_001360899 NM_001360900 RefSeq (protein) NP_001136325 NP_001269363 NP_061115 NP_062352 NP_001347828 NP_001347829 Location (UCSC) Chr 2: 238.24 – 238.24 Mb Chr 1: 91.34 – 91.34 Mb PubMed search [3] [4]
Wikidata
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Interactions

HES6 has been shown to interact with TLE1.^[7]