TLE1

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.^[5][6][7]

TLE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GXR, 2CE8, 2CE9, 4OM2, 4OM3
Identifiers
Aliases	TLE1, ESG, ESG1, GRG1, transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor, TLE-1
External IDs	OMIM: 600189; MGI: 104636; HomoloGene: 21058; GeneCards: TLE1; OMA:TLE1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.32 Start 81,583,683 bp[1] End 81,689,547 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C2 Start 72,035,379 bp[2] End 72,119,156 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone sural nerve endometrium muscle of thigh parotid gland right lobe of liver canal of the cervix ganglionic eminence gastrocnemius muscle middle temporal gyrus Top expressed in Rostral migratory stream external carotid artery seminal vesicula internal carotid artery mandibular prominence ventricular zone ganglionic eminence superior cervical ganglion maxillary prominence vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity transcription factor binding protein binding identical protein binding Cellular component cytosol nucleus nucleoplasm beta-catenin-TCF complex transcription regulator complex cytoplasm nucleolus Biological process regulation of transcription, DNA-templated negative regulation of Wnt signaling pathway Wnt signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling transcription, DNA-templated multicellular organism development positive regulation of gene expression animal organ morphogenesis negative regulation of transcription, DNA-templated negative regulation of anoikis signal transduction negative regulation of transcription by RNA polymerase II beta-catenin-TCF complex assembly negative regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7088 21885 Ensembl ENSG00000196781 ENSMUSG00000008305 UniProt Q04724 Q62440 RefSeq (mRNA) NM_001303103 NM_001303104 NM_005077 NM_001285529 NM_001285530 NM_001285531 NM_001285532 NM_011599 RefSeq (protein) NP_001290032 NP_001290033 NP_005068 NP_001272458 NP_001272459 NP_001272460 NP_001272461 NP_035729 Location (UCSC) Chr 9: 81.58 – 81.69 Mb Chr 4: 72.04 – 72.12 Mb PubMed search [3] [4]
Wikidata
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Interactions

TLE1 has been shown to interact with:

• Glycoprotein 130,^[8]
• HES6,^[9]
• RUNX1,^[10]
• RUNX3,^[10]
• SIX3^[11]
• TLE2,^[12] and
• UTY.^[13]