HIP2

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.^[5][6][7]

UBE2K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YLA, 2O25, 3E46, 3F92, 3K9O, 3K9P, 5DFL
Identifiers
Aliases	UBE2K, E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
External IDs	OMIM: 602846; MGI: 1858216; HomoloGene: 3903; GeneCards: UBE2K; OMA:UBE2K - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 39,698,109 bp[1] End 39,782,792 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.1|5 33.72 cM Start 65,694,576 bp[2] End 65,756,331 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte islet of Langerhans postcentral gyrus Brodmann area 23 middle temporal gyrus amniotic fluid buccal mucosa cell superior frontal gyrus stromal cell of endometrium Top expressed in seminiferous tubule zygote tail of embryo primary oocyte primitive streak secondary oocyte abdominal wall genital tubercle yolk sac hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity transferase activity nucleotide binding ubiquitin-ubiquitin ligase activity protein binding ATP binding ubiquitin protein ligase binding ubiquitin conjugating enzyme activity Cellular component cytoplasm filopodium tip nucleus cytosol Biological process protein K48-linked ubiquitination positive regulation of type I interferon-mediated signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress free ubiquitin chain polymerization positive regulation of peptidyl-threonine phosphorylation ubiquitin-dependent protein catabolic process cellular response to interferon-beta proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3093 53323 Ensembl ENSG00000078140 ENSMUSG00000029203 UniProt P61086 P61087 RefSeq (mRNA) NM_005339 NM_001111112 NM_001111113 NM_001312646 NM_001312647 NM_001312648 NM_032733 NM_016786 NM_001310618 NM_001310619 RefSeq (protein) NP_001104582 NP_001104583 NP_001299575 NP_001299576 NP_001299577 NP_005330 NP_001297547 NP_001297548 NP_058066 Location (UCSC) Chr 4: 39.7 – 39.78 Mb Chr 5: 65.69 – 65.76 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.^[7]

Interactions

HIP2 has been shown to interact with Huntingtin^[5][8] and RNF2.^[9]