RNF2

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.^[5][6]

RNF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H0D, 3GS2, 3H8H, 3IXS, 3RPG, 4R8P, 4S3O
Identifiers
Aliases	RNF2, BAP-1, BAP1, DING, HIPI3, RING1B, RING2, ring finger protein 2, ring1B, LUSYAM
External IDs	OMIM: 608985; MGI: 1101759; HomoloGene: 2199; GeneCards: RNF2; OMA:RNF2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 185,045,526 bp[1] End 185,102,603 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G1 Start 151,333,755 bp[2] End 151,376,706 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence ventricular zone islet of Langerhans stromal cell of endometrium testicle monocyte Achilles tendon epithelium of colon buccal mucosa cell Top expressed in genital tubercle zygote tail of embryo medial ganglionic eminence secondary oocyte Gonadal ridge mandibular prominence atrioventricular valve maxillary prominence primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity chromatin binding RING-like zinc finger domain binding metal ion binding ubiquitin-protein transferase activity protein binding transferase activity zinc ion binding Cellular component euchromatin sex chromatin ubiquitin ligase complex nucleoplasm chromosome heterochromatin MLL1 complex PRC1 complex PcG protein complex nucleus nuclear body Biological process germ cell development histone H2A-K119 monoubiquitination regulation of transcription, DNA-templated gastrulation with mouth forming second histone H2A monoubiquitination negative regulation of transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity transcription, DNA-templated protein ubiquitination mitotic cell cycle anterior/posterior axis specification histone ubiquitination negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6045 19821 Ensembl ENSG00000121481 ENSMUSG00000026484 UniProt Q99496 Q9CQJ4 RefSeq (mRNA) NM_007212 NM_011277 NM_001360844 NM_001360845 NM_001360847 RefSeq (protein) NP_009143 NP_035407 NP_001347773 NP_001347774 NP_001347776 Location (UCSC) Chr 1: 185.05 – 185.1 Mb Chr 1: 151.33 – 151.38 Mb PubMed search [3] [4]
Wikidata
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Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.^[6]

Interactions

RNF2 has been shown to interact with TFCP2^[7] and HIP2.^[5]

See also

• RING finger domain