HIST2H3A

Histone cluster 2 H3 family member a is a protein that in humans is encoded by the HIST2H3A gene.^[5]

H3C15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IIJ, 2X4W, 2X4X, 2X4Y, 3AV1, 3DB3, 3MO8, 3R93, 4MZF, 4MZG, 4MZH, 4OUC, 5BO0, 2HIO, 5B0Z, 2ARO, 1EQZ, 1HQ3, 4KGC, 1TZY, 4UUZ, 2F8N, 5B0Y, 4LD9, 5B40, 5CIU
Identifiers
Aliases	H3C15, H3/n, H3/o, histone cluster 2, H3a, histone cluster 2 H3 family member a, HIST2H3A, H3 clustered histone 15, H3C14, H3C13
External IDs	MGI: 2448329; HomoloGene: 133885; GeneCards: H3C15; OMA:H3C15 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,852,608 bp[1] End 149,853,125 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.1|13 9.78 cM Start 23,728,222 bp[2] End 23,729,482 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells testicle gonad ganglionic eminence ventricular zone apex of heart olfactory zone of nasal mucosa corpus callosum islet of Langerhans Achilles tendon Top expressed in zygote spermatocyte embryo primary oocyte secondary oocyte embryo maxillary prominence mandibular prominence primitive streak morula More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding histone binding protein binding chromatin binding nucleosomal DNA binding Cellular component extracellular exosome extracellular region nucleoplasm chromosome nucleosome nucleus chromatin Biological process epigenetic maintenance of chromatin in transcription-competent conformation blood coagulation rDNA heterochromatin assembly nucleosome assembly negative regulation of gene expression, epigenetic negative regulation of transcription by RNA polymerase II chromatin organization regulation of gene silencing by miRNA interleukin-7-mediated signaling pathway regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 333932 260423 Ensembl ENSG00000203852 ENSMUSG00000100210 UniProt Q71DI3 P84228 RefSeq (mRNA) NM_001005464 NM_013548 RefSeq (protein) NP_066403 NP_001116847 NP_473386 NP_835734 NP_783584 NP_835510 NP_835587 NP_038576 NP_835511 NP_835512 Location (UCSC) Chr 1: 149.85 – 149.85 Mb Chr 13: 23.73 – 23.73 Mb PubMed search [3] [4]
Wikidata
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Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on human chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015].