HNRPUL1

Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene.^[5][6][7]

HNRNPUL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZRJ
Identifiers
Aliases	HNRNPUL1, E1B-AP5, E1BAP5, HNRPUL1, heterogeneous nuclear ribonucleoprotein U like 1
External IDs	OMIM: 605800; MGI: 2443517; HomoloGene: 31419; GeneCards: HNRNPUL1; OMA:HNRNPUL1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,262,496 bp[1] End 41,307,787 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 25,420,590 bp[2] End 25,454,182 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence sural nerve gastric mucosa left ovary stromal cell of endometrium right ovary bone marrow cells body of uterus popliteal artery Top expressed in internal carotid artery Gonadal ridge external carotid artery genital tubercle molar mesenteric lymph nodes Rostral migratory stream tail of embryo conjunctival fornix ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding protein binding RNA binding Cellular component nucleus nucleoplasm Biological process mRNA splicing, via spliceosome response to virus RNA processing regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11100 232989 Ensembl ENSG00000105323 ENSMUSG00000040725 UniProt Q9BUJ2 Q8VDM6 RefSeq (mRNA) NM_001301016 NM_007040 NM_144732 NM_144733 NM_144734 NM_001321208 NM_001321211 NM_144922 NM_178089 NM_001360789 RefSeq (protein) NP_001287945 NP_001308137 NP_001308140 NP_008971 NP_653333 NP_659171 NP_835190 NP_001347718 Location (UCSC) Chr 19: 41.26 – 41.31 Mb Chr 7: 25.42 – 25.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined.^[7]

Interactions

HNRPUL1 has been shown to interact with BRD7^[6] and PRMT2.^[8]